ReviewHealth science reports2026
Effectiveness of LDL Apheresis Techniques for Reducing LDL-C in Familial Hypercholesterolemia: A Systematic Review and Meta-Analysis.
Review in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Familial hypercholesterolemia (FH) is a common inherited disorder characterized by markedly elevated low-density lipoprotein cholesterol (LDL-C) levels and an increased risk of premature cardiovascular disease. LDL apheresis is an extracorporeal procedure used to remove atherogenic lipoproteins from the circulation and is an established treatment option for selected patients with FH. This study aimed to systematically review and meta-analyze the effectiveness of different LDL apheresis techniques in reducing LDL-C and other lipid parameters in patients with FH. Methods: A systematic review and meta-analysis was conducted on 9 March, 2025. PubMed/MEDLINE, Scopus, Web of Science Core Collection, EMBASE, and Google Scholar were searched using relevant keywords and Medical Subject Headings (MeSH) terms, without restrictions on publication date or publication status. Data were extracted and managed using EndNote and Microsoft Excel, and statistical analyses were performed using Stata 2017. The methodological quality of the included studies was assessed using appropriate Joanna Briggs Institute (JBI) critical appraisal checklists. Subgroup and sensitivity analyses were performed to explore potential differences according to study characteristics. Random-effects models were used to account for between-study heterogeneity. Results: Of 1060 records identified through database and reference-list searches, 33 studies met the inclusion criteria. Germany contributed the largest number of included studies ( Conclusion: LDL apheresis was associated with substantial reductions in TC, LDL-C, HDL-C, TG, and Lp(a) in patients with FH. The available evidence suggests that different LDL apheresis techniques have broadly comparable effects on TG and Lp(a), whereas DFPP demonstrated greater reductions in TC, LDL-C, and HDL-C in the available comparative evidence. However, the safety evidence should be interpreted cautiously because adverse events were not quantitatively synthesized and reporting varied across studies. Therefore, the available evidence does not permit definitive conclusions regarding the comparative safety of LDL apheresis techniques. In clinical practice, selection of a specific technique should consider treatment characteristics, patient tolerance, technical requirements, resource availability, and cost considerations in addition to lipid-lowering efficacy.
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