Evidence map›Paper›PMID 42859698›Full record

ArticleReviews in cardiovascular medicine2026

Skirted Prosthetic Valves Are Associated With Increased Risk of Subclinical Leaflet Thrombosis Following Transcatheter Aortic Valve Replacement: A Multicenter Study.

Yifan Yang, Qiang Li, Jing Yao, Yunfeng Yan, Moyang Wang, Xinmin Liu, Fei Yuan, Zhengming Jiang, Taiyang Luo, Qian Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reviews in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yifan YangInterventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.ORCID https://orcid.org/0009-0003-1154-9410
Qiang LiInterventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.ORCID https://orcid.org/0000-0002-4897-1012
Jing YaoInterventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Yunfeng YanInterventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Moyang WangDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, 100037 Beijing, China.
Xinmin LiuInterventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Fei YuanInterventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Zhengming JiangInterventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Taiyang LuoInterventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Qian ZhangInterventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.
Yongjian WuDepartment of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, 100037 Beijing, China.
Guangyuan SongInterventional Center of Valvular Heart Disease, Beijing Anzhen Hospital, Capital Medical University, 100029 Beijing, China.ORCID https://orcid.org/0000-0002-7868-6132

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Subclinical leaflet thrombosis (SLT) is associated with an increased risk of thromboembolic events, valve dysfunction, and mortality in patients undergoing transcatheter aortic valve replacement (TAVR). However, data on the incidence and risk factors for SLT in patients undergoing TAVR using self-expanding valves (SEVs) remain limited. Methods: This study included patients who underwent TAVR using SEVs and received a postoperative four-dimensional computed tomography scan within six months at Beijing Anzhen Hospital and Fuwai Hospital. SLT was defined as the presence of hypo-attenuated leaflet thickening (HALT) with or without reduced leaflet motion (RLM), and characterized by increased leaflet thickness affecting one or more leaflets. Univariate and multivariable logistic regression analyses were conducted to explore the relationship between variables and the occurrence of SLT. Results: A total of 311 patients (mean age 72.02 ± 8.23 years, 52.4% males) were included in the analysis. HALT was detected in 91 patients (29.3%), while RLM was observed in 45 patients (14.5%). Most HALT (81.3%) and RLM (73.3%) cases were classified as grades 1-2. Multivariable logistic regression analysis revealed that using skirted prosthetic valves was significantly associated with SLT (adjusted odds ratio: 2.999; 95% confidence interval: 1.250-7.397; Conclusions: Over one-quarter of patients undergoing TAVR using SEVs developed SLT within six months. The use of skirted prosthetic valves was independently associated with SLT.

Indexed as

hypo-attenuated leaflet thickeningself-expanding valvessubclinical leaflet thrombosistranscatheter aortic valve replacement

Identifiers

PMID42859698
PMCPMC13653166

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.