ArticleAging medicine (Milton (N.S.W))2026
Cerebral Hemodynamic Changes in Older Adults With Cognitive Complaints According to the Presence of Peripheral Artery Disease.
Article in Aging medicine (Milton (N.S.W)), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: As a systemic expression of atherosclerosis, peripheral artery disease (PAD) has the potential to alter cerebral hemodynamics in elderly individuals presenting with cognitive concerns. However, how PAD status shapes the longitudinal trajectory of cerebral hemodynamics has not been well characterized. Methods: We conducted a single-center longitudinal observational study enrolling 132 participants (21 controls, 39 mild cognitive impairment, 72 mild Alzheimer's disease). All participants underwent transcranial Doppler (TCD) ultrasonography, ankle-brachial index (ABI) measurement, brain MRI, and cognitive assessments at baseline and follow-up (~13.45 months). PAD was defined as ABI < 0.90. Bilateral mean flow velocity (MFV), pulsatility index (PI), and resistance index (RI) of the middle cerebral artery (MCA) were tracked longitudinally across both time points. Results: PAD was identified in 13 participants (9.8%). Baseline TCD parameters, vascular risk factors, white matter lesions on brain MRI, and cognitive measures were comparable between groups. At follow-up, the PAD group showed significantly higher MCA MFV after age adjustment (left Conclusion: These findings identify PAD as a condition associated with progressive MCA MFV elevation in the context of preserved cognition, implying that subclinical cerebrovascular changes are detectable by TCD before overt clinical worsening. Future research involving larger cohorts and extended follow-up is required to determine whether such hemodynamic changes forecast eventual cognitive deterioration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.