ArticleCureus2026
Characterization and Antimicrobial Susceptibility Patterns of Clinically Significant Non-fermenting Gram-Negative Bacilli Isolated From Clinical Specimens.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
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Abstract
Background Non-fermenting Gram-negative bacilli (NFGNB) have emerged as significant opportunistic pathogens associated with infections in healthcare settings and multidrug resistance. Their ability to persist in hospital settings and develop resistance to multiple antimicrobial agents poses a serious challenge to patient management. The current study aimed to determine the distribution of NFGNB isolates across different clinical samples and to evaluate their antimicrobial susceptibility and multidrug resistance patterns. Materials and methods A cross-sectional investigation was carried out on 127 NFGNB that were isolated from clinical samples received in the Department of Microbiology Laboratory of a tertiary care hospital. Antimicrobial susceptibility testing was performed in accordance with the Clinical and Laboratory Standards Institute (CLSI) guidelines, and the isolates were identified using conventional microbiological techniques. Demographic characteristics, specimen distribution, bacterial profile and multidrug resistance patterns were studied. Results A total of 127 NFGNB isolates were recovered, of which 86 (67.72%) were from male patients and 41 (32.28%) were from female patients. The highest prevalence of NFGNB was observed in the 61-70-year age group, with 26 (20.47%) isolates, followed by the 51-60-year age group, with 23 (18.11%) isolates. Endotracheal (ET) aspirates were the most common specimen source, accounting for 34 (26.77%) isolates, followed by pus/discharge/wound swabs with 27 (21.26%) and urine with 26 (20.47%) isolates. 88 (69.29%) of the NFGNB isolates were obtained from patients admitted to the intensive care unit, whereas 39 (30.71%) were isolated from patients admitted to the wards.
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