Evidence map›Paper›PMID 42859650›Full record

ArticleHuman mutation2026

Somatic Mutation-Informed Transcriptional Architecture of Hepatocellular Carcinoma: A Multiomics Study Centered on

Sheng Zhang, Guojun Zhang, Wenxuan Wang, Hong Luo, Huaping Chen

Abstract read
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sheng ZhangDepartment of Radiology Beijing Anzhen Nanchong Hospital of Medical University and Nanchong Central Hospital Nanchong China.
Guojun ZhangDepartment of Oncology Beijing Anzhen Nanchong Hospital of Medical University and Nanchong Central Hospital Nanchong China.
Wenxuan WangDepartment of Radiology Beijing Anzhen Nanchong Hospital of Medical University and Nanchong Central Hospital Nanchong China.
Hong LuoDepartment of Radiology Beijing Anzhen Nanchong Hospital of Medical University and Nanchong Central Hospital Nanchong China.
Huaping ChenDepartment of Radiology Beijing Anzhen Nanchong Hospital of Medical University and Nanchong Central Hospital Nanchong China.ORCID https://orcid.org/0009-0009-9769-2595

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is characterized by extensive somatic mutation heterogeneity, yet the cellular contexts in which recurrent driver mutation-associated transcriptional programs operate remain incompletely defined. In this study, we applied a mutation-informed multiomics framework centered on

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMutationTranscription, GeneticTumor Suppressor Protein p53Gene Expression ProfilingGene Expression Regulation, NeoplasticHumansMultiomicsSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisTranscriptomeTP53 protein, humanTumor Suppressor Protein p53hepatocellular carcinomamultiomics integrationsingle-cell RNA sequencingsomatic mutationTP53 mutationtranscriptional heterogeneitytumor genomics

Identifiers

PMID42859650
PMCPMC13653071

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.