Evidence map›Paper›PMID 42859646›Full record

ArticleInternational journal of hepatology2026

LOX-1 and Its Splicing Variant LOX-1

Martina Puzzuoli, Maria Giovanna Scioli, Chiara Greggi, Silvia Anzillotti, Beatrice Belmonte, Sonia Terriaca, Amedeo Ferlosio, Sabina Pucci, Augusto Orlandi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martina PuzzuoliDept. of Biomedicine and Prevention University of Rome "Tor Vergata" Rome Italy uniroma2.it.
Maria Giovanna ScioliDept. of Biomedicine and Prevention University of Rome "Tor Vergata" Rome Italy uniroma2.it.ORCID https://orcid.org/0000-0002-8458-4108
Chiara GreggiPoliclinico Tor Vergata Rome Italy ptvonline.it.ORCID https://orcid.org/0000-0003-3205-4030
Silvia AnzillottiDept. of Biomedicine and Prevention University of Rome "Tor Vergata" Rome Italy uniroma2.it.ORCID https://orcid.org/0009-0001-0764-0495
Beatrice BelmonteTumor Immunology Unit Department of Health Sciences University of Palermo Palermo Italy unipa.it.ORCID https://orcid.org/0000-0001-9668-0925
Sonia TerriacaPoliclinico Tor Vergata Rome Italy ptvonline.it.ORCID https://orcid.org/0000-0001-5117-7699
Amedeo FerlosioDept. of Biomedicine and Prevention University of Rome "Tor Vergata" Rome Italy uniroma2.it.
Sabina PucciDept. of Biomedicine and Prevention University of Rome "Tor Vergata" Rome Italy uniroma2.it.
Augusto OrlandiDept. of Biomedicine and Prevention University of Rome "Tor Vergata" Rome Italy uniroma2.it.ORCID https://orcid.org/0000-0001-7202-5854

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatocellular carcinoma (HCC) is a leading cause among cancer-related deaths. HCC progression is linked to alteration of lipid metabolism. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), a receptor for oxidized low-density lipoproteins (ox-LDLs), and its splicing isoform LOX-1 Methods: We performed in vivo evaluation of LOX-1 expression on HCC tissue samples by immunohistochemistry and in vitro transfection studies on HCC cell line HepG2 to verify the involvement of LOX-1 and its variant LOX-1 Results: Total LOX-1 expression correlated with higher tumor grade in HCC tissue samples. LOX-1 Conclusions: LOX-1

Indexed as

cancer progressionchemoresistancehepatocellular carcinomaLOX-1LOX-1Δ4

Identifiers

PMID42859646
PMCPMC13653080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.