ArticleThe Lancet regional health. Europe2026
Clinical practice guidelines for neonatal therapeutic hypothermia across European Society for Paediatric and Neonatal Intensive Care (ESPNIC) member countries: a multidisciplinary blind comparison.
Article in The Lancet regional health. Europe, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Background: Therapeutic hypothermia (TH) decreases mortality and neuro-developmental disability in neonates greater or equal than 36 weeks' gestation with moderate-to-severe hypoxic-ischaemic encephalopathy (HIE) due to perinatal asphyxia. TH is often applied in different ways, as national guidelines and target populations may significantly differ. We aimed to compare TH guidelines from various European countries as we hypothesised that guidelines are significantly different and often of insufficient quality. Methods: Multidisciplinary, blind, critical appraisal of clinical practice guidelines using AGREE-II and RIGHT tools to assess their quality and completeness of the reporting, respectively. The appraisal was performed by neonatologists, obstetricians, paediatric and adult intensivists. The raters were kept unaware of the identity of the other panellists and each of them performed the evaluation of the guidelines independently. Findings: Total AGREE-II score was different amongst the guidelines ( Interpretation: European guidelines for neonatal TH have a general insufficient quality and completeness of reporting. Fundings: None.
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