ArticleArhiv za higijenu rada i toksikologiju2026
Tissue-specific variability in protein expression of cytochrome P450 and glutathione S-transferase isoenzymes in non-small cell lung carcinoma.
Article in Arhiv za higijenu rada i toksikologiju, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Earlier tissue-based studies report heterogeneous CYP and GST protein expression in non-small cell lung cancer (NSCLC), but simultaneous assessment of phase I and II enzymes in paired tumour and peripheral normal tissues remains limited and their expression patterns poorly characterised across the two major NSCLC histological subtypes, namely adenocarcinoma (AC) and squamous cell carcinoma (SCC). To address these gaps, this retrospective study evaluated CYP1A1, CYP1B1, CYP2E1, GSTM1, GSTT1, and GSTP1 expression immunohistochemically in tumour and peripheral normal lung tissues of 50 patients with NSCLC, 27 of whom with AC and 23 with SCC. Cytoplasmic staining intensity was scored from 0 to 3. Tissue and subtype comparisons were performed using the Mann-Whitney
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