Evidence map›Paper›PMID 42859372›Full record

ArticleChinese journal of integrative medicine2026

Maxing Shigan Decoction Regulates Immune Inflammatory Response of Adenovirus Pneumonia by Inhibiting cGAS-STING Pathway.

Si-Wei Wang, Cheng Peng, Li Deng, Guo-Qian Cong, Feng Yan, Jun-Fu Na, Li-Jian Pang

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Article in Chinese journal of integrative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Si-Wei WangFirst Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, China.
Cheng PengDepartment of Clinical Laboratory, the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, China.
Li DengDepartment of Clinical Laboratory, the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, China.
Guo-Qian CongDepartment of Clinical Laboratory, the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, China.
Feng YanDepartment of Clinical Laboratory, the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, China.
Jun-Fu NaDepartment of Clinical Laboratory, the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, China.
Li-Jian PangDepartment of Clinical Laboratory, the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, China. 15940540323@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether Maxing Shigan Decoction (MSD) regulates the immune-inflammatory response of adenovirus pneumonia (AVP) by inhibiting the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway.

methodsA mouse model of AVP was induced by intranasal instillation of human adenovirus type 3 (Ad3), and Raw264.7 cells were infected with Ad3 to establish an in vitro model. The in vivo and in vitro experiments both included 6 groups: control, model, ribavirin (RIB), and low- (MSD-L), medium- (MSD-M), and high-dose MSD (MSD-H) groups. Moreover, the cGAS-STING pathway agonist SR-717 was used during the cell experiment. Hematoxylin and eosin (HE) staining was conducted to identify pathological changes in the lung tissue of AVP mice. The quantity of CD3

resultsIn vivo, MSD and RIB significantly reduced lung tissue inflammation in the AVP mouse model, and reduced the excessive immune response mediated by CD3

conclusionsMSD modulated the immune inflammatory response in AVP by inhibiting the cGAS-STING pathway. It protected lung tissue from damage caused by excessive immune responses and inflammatory reactions.

Indexed as

adenovirus pneumoniacGAS-STINGChinese medicineimmune responseinflammationMaxing Shigan Decoction

Identifiers

PMID42859372

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