Evidence map›Paper›PMID 42859338›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2026

Metabolic basis of post-infectious sequelae after Ebola virus disease.

Anna C Sanford, Nell G Bond, Samuel Ficenec, Charlotte Osterman, Payton Farkas, Emily Engel, Bronwyn Gunn, Donald S Grant, Robert Samuels, Kevin J Zwezdaryk and 1 more

Abstract read
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Article in Metabolomics : Official journal of the Metabolomic Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Anna C SanfordDepartment of Pediatrics, Tulane University School of Medicine, 1430 Tulane Ave, Box 8408, New Orleans, LA, 70112, USA. asanford@tulane.edu.ORCID http://orcid.org/0000-0003-2275-4535
Nell G BondTulane University, New Orleans, LA, USA.
Samuel FicenecTulane University, New Orleans, LA, USA.
Charlotte OstermanTulane University, New Orleans, LA, USA.
Payton FarkasTulane University, New Orleans, LA, USA.
Emily EngelTulane University, New Orleans, LA, USA.
Bronwyn GunnWashington State University, Pullman, WA, USA.
Donald S GrantKenema Government Hospital, Kenema, Sierra Leone.
Robert SamuelsTulane University, New Orleans, LA, USA.
Kevin J ZwezdarykTulane University, New Orleans, LA, USA.
John S SchieffelinTulane University, New Orleans, LA, USA.

Funding

Clinical Sequelae and Urogenital Viral Dynamics in Survivors of Ebola Virus DiseaseR01AI123535 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISCHER, WILLIAM, WOHL, DAVID A · 2017 to 2021
$3.3M
The Role of Viral Exposure and Age in Alzheimer's Disease ProgressionR01AG082899 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI Kevin John Zwezdaryk · 2023 to 2026
$2.1M
Tulane StARR ProgramR38HL155774 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JAY K KOLLS, Marie Krousel-Wood · 2021 to 2026
$1.5M
NHLBI NIH HHS R38 HL155774NIAID NIH HHS R01 AI123535NIA NIH HHS R01 AG082899NIH HHS 1R01AG082899NIH HHS 1R01AI123535NIH HHS R38HL155774
6 · The paper itself

Abstract

introductionEbola virus disease (EVD) survivors often present with clinical sequelae after acute disease resolution, called post-Ebola syndrome (PES). Why some survivors develop these sequelae and others do not is poorly defined. Altered metabolism has been noted in acute EVD but has not been studied in PES. Here, we identified distinct metabolic pathways in EVD survivors with PES compared to asymptomatic survivors and potential biomarkers of PES.

objectivesThe purpose of this study was to determine if EVD survivors with PES demonstrated differential metabolism compared to asymptomatic EVD survivors.

methodsPlasma was collected from EVD survivors in Sierra Leone as part of an ongoing cohort study. Untargeted metabolomics (LC-MS/MS) was performed on survivors with and without sequelae as well as household contacts. Univariate, multivariate, biomarker and pathway analyses were performed in MetaboAnalyst. Spearman's R correlation was performed using JMP.

resultsWe identified differential expression of metabolites involved in multiple metabolic pathways in EVD survivors with PES compared to asymptomatic survivors. These pathways include the tricarboxylic acid cycle as well as amino acid, nucleotide, and short chain fatty acid metabolism. Several of these pathways are associated with immune dysfunction. The identified metabolites have potential use as biomarkers of PES.

conclusionEVD survivors with PES exhibit differing metabolism compared to asymptomatic EVD survivors in several pathways. Other studies have linked these pathways to immune dysfunction and chronic viral infection, however further immunometabolic studies of EVD survivors with PES are needed.

Indexed as

Hemorrhagic Fever, EbolaAdultBiomarkersChromatography, LiquidCohort StudiesFemaleHumansMaleMetabolic Networks and PathwaysMetabolomeMetabolomicsPost-Infectious DisordersSurvivorsTandem Mass SpectrometryBiomarkers

Identifiers

PMID42859338
PMCPMC13653831

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.