ArticleGeroScience2026
Bone marrow myeloid skewing and preserved immunoregulation in hip osteoarthritis of elderly patients.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Osteoarthritis (OA) is increasingly recognized as a disease involving low-grade inflammation and immune remodeling, yet the contribution of the bone marrow (BM) myeloid compartment to hip OA remains poorly defined. Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells with immunoregulatory activity and potential roles in inflammatory bone disease. Here, we investigated ex vivo BM myeloid composition and the functional properties of BM-MDSCs in elderly patients with hip OA compared with patients undergoing surgery for proximal femoral fracture. BM aspirates from both cohorts were analyzed by flow cytometry and cultured with G-CSF and GM-CSF to induce BM-MDSCs. Despite the lower mean age of the hip osteoarthritis cohort, these patients showed a significantly higher proportion of BM myeloid cells than fracture patients, whereas lymphoid cell frequencies were not significantly different. Analysis of myeloid maturation stages revealed enrichment of CD11b⁺/CD16
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