ArticleMolecular biology reports2026
Anti-inflammatory effects of JI-017 in cellular and an LPS-induced endotoxemia model.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionSepsis is a life-threatening condition characterized by dysregulated inflammatory responses and excessive cytokine production, leading to multi-organ dysfunction. Despite advances in supportive care, effective pharmacological strategies to directly modulate sepsis-associated inflammation remain limited. JI-017 is a multi-herbal formulation composed of Angelica gigas, Aconitum carmichaeli Debeaux, and Zingiber officinale Roscoe (2:1:1), previously studied for its anticancer properties.
methodsThe anti-inflammatory effects of JI-017 were evaluated using an integrative approach combining in silico analysis, in vitro macrophage assays, and an in vivo lipopolysaccharide (LPS)-induced endotoxemia model. RAW 264.7 macrophages were used to assess nitric oxide production, cytokine expression, and inflammatory signaling pathways. In vivo effects were evaluated through survival analysis, serum cytokine measurement, and histopathological examination.
resultsJI-017 significantly reduced nitric oxide production and suppressed inflammatory cytokine and chemokine expression in LPS-stimulated RAW 264.7 macrophages. In vivo, JI-017 was associated with improved survival and attenuated systemic and hepatic inflammatory responses in an LPS-induced endotoxemia model. Under the experimental conditions examined, JI-017 did not reduce LPS-induced phosphorylation of the selected MAPK and NF-κB signaling proteins.
conclusionUnder the experimental conditions examined, JI-017 reduced inflammatory responses and was associated with improved survival in an acute LPS-induced endotoxemia model. These findings support further preclinical investigation of JI-017.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.