Evidence map›Paper›PMID 42859210›Full record

ArticleMolecular psychiatry2026

The role of white matter microstructure in the association between childhood maltreatment and adult post-traumatic symptoms.

Luisa Berger, Philine Rojczyk, Johanna Seitz-Holland, Fan Zhang, Lara Pankatz, Nico Sollmann, Elisabeth Kaufmann, Holly Carrington, Twishi Puri, Michael J Coleman and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Luisa Berger *Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.ORCID http://orcid.org/0009-0001-4980-9017
Philine Rojczyk *Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.
Johanna Seitz-HollandPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.ORCID http://orcid.org/0000-0002-1815-2681
Fan ZhangPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.
Lara PankatzPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.
Nico SollmannPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.
Elisabeth KaufmannPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.ORCID http://orcid.org/0000-0002-7582-2215
Holly CarringtonPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.
Twishi PuriPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.
Michael J ColemanPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.
Ofer PasternakPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.ORCID http://orcid.org/0000-0002-7078-6446
Sylvain BouixPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.ORCID http://orcid.org/0000-0003-1326-6054
Yogesh RathiPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.
Suheyla Cetin-KarayumakPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.ORCID http://orcid.org/0000-0002-3315-5821
Lauren J O'DonnellDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0197-7801
Peter FalkaiDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-0284-2290
Mark S GeorgePsychiatry Department, Medical University of South Carolina, Charleston, USA.
Thomas W McAllisterDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, USA.
Ross ZafonteDepartment of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Charlestown, USA.
Murray B SteinDepartment of Psychiatry, University of California San Diego, La Jolla, USA.ORCID http://orcid.org/0000-0001-9564-2871
Martha E ShentonPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA.ORCID http://orcid.org/0000-0003-4235-7879
Inga K KoertePsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Somerville, MA, USA. ikoerte@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-1281-9286

Funding

Mapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRIR01MH125860 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2021 to 2025
$4.1M
Harmonizing multi-site diffusion MRI acquisitions for neuroscientific analysis across ages and brain disordersR01MH119222 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI O'DONNELL, LAUREN JEAN, RATHI, YOGESH · 2019 to 2023
$4.0M
Mapping of the intrinsic and extrinsic cerebellar connectome at ultra high resolution with expert neuroanatomical curationR01MH132610 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2023 to 2025
$2.6M
CRCNS:Subject-Specific Difusion MRI Profiles of Injury in TBI and PTSDR01HD090641 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BOUIX, SYLVAIN · 2016 to 2018
$810k
Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01GL2406AU.S. Department of Defense (United States Department of Defense) W81XWH-08-2-0159U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01HD090641U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01MH119222U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01MH125860U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01MH132610
6 · The paper itself

Abstract

Childhood maltreatment (CM) is a risk factor for adult post-traumatic symptoms and white matter (WM) alterations. It remains unknown how WM microstructure is affected alongside two common military conditions, post-traumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI). Data from 299 participants (53% male, 35.69 ± 12.23 years of age) of the Injury and Traumatic Stress (INTRuST) clinical consortium was analyzed. The study included 56 individuals with PTSD (41 with comorbid mTBI), 107 with mTBI, and 136 controls (no PTSD and/or mTBI). Diffusion parameters (mean, axial, and radial diffusivity, MD, AD, RD; fractional anisotropy, FA) in major WM tracts were extracted from diffusion MRI. CM was assessed using the Childhood Trauma Questionnaire (CTQ). Multiple regression models examined associations between CM severity and WM diffusion. Moderation analyses assessed the effect of PTSD and/or mTBI on these associations. Mediation analyses examined how WM diffusion affects the associations between CM and both PTSD and post-concussive symptom severity. Greater CM severity was associated with lower MD and AD, independent of PTSD and/or mTBI. WM diffusion, particularly in the corpus callosum and the superior longitudinal fasciculus, mediated the associations between CM severity and both PTSD (MD b

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PMID42859210

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.