Evidence map›Paper›PMID 42859199›Full record

ArticleInternational journal of obesity (2005)2026

Disrupted daily rhythms in light exposure and wrist temperature are associated with metabolic risk markers and obesity.

Ivan Dozzani, María Rodríguez-Martín, Hassan S Dashti, Céline Vetter, Jesualdo T Fernández-Breis, J C Florez, Richa Saxena, Frank A J L Scheer, Marta Garaulet

Registry-linked trialAbstract read
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In one paragraph

Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03036592 (MTNR1B SNP*Food Timing Interaction on Glucose Control in a Late Eater Mediterranean Population), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03036592 nacompletednot on this map

MTNR1B SNP*Food Timing Interaction on Glucose Control in a Late Eater Mediterranean Population

TypeinterventionalSponsorUniversidad de MurciaRan2017 to 2020Enrolled889ConditionsNon-Diabetic Disorder of Endocrine PancreasArmsEarly OGTT, Late OGTT
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ivan Dozzani *Department of Physiology, University of Murcia, Murcia, Spain.
María Rodríguez-Martín *Department of Physiology, University of Murcia, Murcia, Spain.
Hassan S DashtiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1650-679X
Céline VetterDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Jesualdo T Fernández-BreisNutrition Group of Research, Biomedical Research Institute of Murcia Pascual Parrilla-IMIB, Murcia, Spain.ORCID http://orcid.org/0000-0002-7558-2880
J C FlorezBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.
Richa SaxenaDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2233-1065
Frank A J L ScheerBroad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2014-7582
Marta GarauletDepartment of Physiology, University of Murcia, Murcia, Spain. garaulet@um.es.ORCID http://orcid.org/0000-0002-4066-3509

Funding

Role of Meal Timing in Efficacy of Bariatric Surgery in Obese IndividualsR01HL140574 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A, TAVAKKOLI, ALI · 2017 to 2023
$4.2M
Food Timing to Mitigate Adverse Consequences of Night WorkR01HL153969 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2021 to 2025
$3.9M
Impact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK105072 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2016 to 2020
$3.2M
NHLBI NIH HHS R01 HL140574NHLBI NIH HHS R01 HL153969NIDDK NIH HHS R01 DK105072
6 · The paper itself

Abstract

BACKGROUND/

objectivesLight exposure is the primary external synchronizer of the body's internal clocks and daily rhythms. This study investigated whether light exposure and wrist temperature real-life 24-h rhythms are associated with obesity and metabolic risk markers in a large cohort of healthy adults. SUBJECTS/

methodsA total of 809 individuals from the ONTIME-MT study (ClinicalTrials.gov NCT03036592) were included. Mean age was 37.47 ± 14.24 years, mean BMI was 25.75 kg/m², and 71% were women. Daily light exposure and wrist temperature were continuously monitored over seven consecutive days under free-living conditions. Principal component analysis was used to identify factors capturing circadian-related functioning.

designCross-sectional study.

settingHealthy adults of European descent from a Spanish cohort assessed in an ambulatory setting.

main outcome measuresObesity-related and metabolic risk parameters.

resultsThree factors emerged in both the light exposure and wrist temperature rhythm domains, explaining approximately 73% and 80% of the total variance. In both domains, Factor 1 accounted for the largest proportion of variance (≈41-42%) and reflected overall rhythm robustness, characterized by higher relative amplitude and greater interdaily stability, together with average light exposure or wrist temperature levels. Higher light exposure Factor 1 was associated with lower serum triglyceride concentrations (P = 0.013). Wrist temperature Factor 1 was associated with lower BMI and body fat percentage in women, as well as lower insulin, HOMA-IR and triglyceride levels, and higher HDL-cholesterol (all P < 0.05). Mediation analyses showed that interdaily stability of wrist temperature rhythms may affect the association between light exposure stability and triglyceride levels, accounting for approximately 11% of the total effect (P = 0.021).

conclusionsIn this large real-life cohort, less robust daily rhythms of light exposure and wrist temperature were consistently associated with adverse metabolic profiles. These findings highlight the potential of circadian-related markers derived from wearable technologies as non-invasive indicators of metabolic risk. CLINICAL TRIAL NUMBER: ONTIME-MT study; ClinicalTrials.gov NCT03036592.

Identifiers

PMID42859199

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.