Evidence map›Paper›PMID 42859082›Full record

ReviewTrends in neurosciences2026

The mitochondrial epigenome and noncoding genome in aging and brain diseases.

Abd-El-Monsif A Shawky, Hui-Ting Huang, Dhruv Parikh, Kahlilia C Morris-Blanco

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abd-El-Monsif A ShawkyDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; National Institutes of Health/National Cancer Institute, Bethesda, MD 20892, USA.
Hui-Ting HuangDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dhruv ParikhDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Emory University, Atlanta, GA 30322, USA.
Kahlilia C Morris-BlancoDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Epigenetics Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. Electronic address: Kahlilia.blanco@pennmedicine.upenn.edu.

Funding

Training in Molecular Therapeutics for Pediatric CardiologyT32HL007915 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Robert J Levy, JOSEPH W ROSSANO · 1999 to 2026
$13.4M
NHLBI NIH HHS T32 HL007915
6 · The paper itself

Abstract

The mitochondrial genome is a dynamic regulatory platform that extends far beyond its protein-coding capacity. Mitochondrial DNA (mtDNA) harbors epigenetic modifications and produces diverse noncoding RNAs that influence mitochondrial function and cellular homeostasis. Evidence from animal models and human studies indicates that mtDNA methylation, mitochondrial-encoded noncoding RNAs, and cytosolic release of mitochondrial nucleic acids regulate transcription, metabolism, and stress signaling. Furthermore, these mechanisms are altered in aging, neurodegenerative disease, and acute brain injury. In this review, we synthesize emerging insights into how the mitochondrial epigenome and noncoding genome shape mitochondrial function and serve as regulatory interfaces linking cellular stress and neuronal vulnerability in brain aging and disease.

Indexed as

DNA methylationdouble-stranded RNAlong noncoding RNAsmecciRNAsmitochondrial epigeneticsneurodegenerative disease

Identifiers

PMID42859082
PMCPMC13660430

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.