ReviewUltrasonics sonochemistry2026
Ultrasound-assisted deep eutectic solvents extraction of bioactive natural products: a sustainable alternative to conventional extraction techniques.
Review in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural products derived from medicinal plants, including purified compounds and standardized extracts, remain important sources of drug leads due to their exceptional structural and chemical diversity. However, their efficient recovery is often limited by complex plant matrices, low target concentrations, and the thermal sensitivity of many bioactive constituents. Consequently, extraction strategies must achieve high recovery while preserving compound stability and biological functionality. Ultrasound-assisted extraction (UAE) has emerged as a promising green technology that enhances cell disruption and mass transfer through acoustic cavitation, thereby reducing extraction time, energy demand, and solvent consumption compared with conventional methods. In parallel, deep eutectic solvents (DES) and natural deep eutectic solvents (NADES) have attracted considerable attention as alternatives to traditional organic solvents because of their low volatility, compositional tunability, and high solubilization capacity. Their combination with ultrasound offers a synergistic platform in which cavitation accelerates matrix disintegration and molecular transport, while DES/NADES provide adaptable extraction environments for chemically diverse compounds. This review critically evaluates the use of DES/NADES for the recovery of alkaloids, anthocyanins, carotenoids, flavonoids, polyphenols, polysaccharides, terpenoids, and xanthones using UAE. It places particular emphasis on solvent design, extraction mechanisms, operating variables, biological activity, and reported extraction performance. This review also examines current limitations in viscosity, solvent recovery, toxicity assessment, standardization, scale-up, and regulatory acceptance. Future progress will depend on integrating solvent engineering, mechanistic modelling, process intensification, and sustainability assessment to enable industrial application in pharmaceutical, food, cosmetic, and nutraceutical production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.