Evidence map›Paper›PMID 42858449›Full record

ReviewReviews in medical virology2026

Does COVID-19 Vaccination Protect Against Post-COVID Cardiovascular Conditions?

Lidian Franci Batalha Santa Maria, Márcio Coutinho Xavier Naves, Elisabeth Carmen Duarte, Isis Polianna Silva Ferreira de Carvalho, Henry Maia Peixoto

Abstract readReview
In one paragraph

Review in Reviews in medical virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lidian Franci Batalha Santa MariaFaculty of Medicine, Center of Tropical Medicine, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília, Brazil.ORCID https://orcid.org/0000-0002-3307-5186
Márcio Coutinho Xavier NavesCardiology and Transplant Institute of the Federal District, Brasília, Brazil.ORCID https://orcid.org/0009-0008-4922-6349
Elisabeth Carmen DuarteFaculty of Medicine, Center of Tropical Medicine, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília, Brazil.
Isis Polianna Silva Ferreira de CarvalhoDepartment of Science and Technology, Secretariat of Science, Technology, Innovation and Health Complex, Ministry of Health, Brasília, Brazil.
Henry Maia PeixotoFaculty of Medicine, Center of Tropical Medicine, Campus Universitário Darcy Ribeiro, University of Brasilia, Brasília, Brazil.ORCID https://orcid.org/0000-0001-5982-8855

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico Process: 445276/2023-1;Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorDepartment of Science and Technology under the Secretariat of Science, Technology, Innovation, and Health Complex of the Ministry of Health Process: 445276/2023-1
6 · The paper itself

Abstract

Cardiovascular diseases, such as acute myocardial infarction, heart failure, and arrhythmias, have been associated with SARS-CoV-2 infection, representing an important cause of long-term morbidity and mortality. In addition to preventing primary infection, COVID-19 vaccination has emerged as a protective factor against post-COVID cardiovascular outcomes. This study aims to analyse the evidence supporting a causal relationship between COVID-19 vaccination and the prevention of post-COVID cardiovascular conditions, based on classical and contemporary epidemiological criteria, including the Bradford Hill criteria (BHC) and the sufficient component cause (SCC) model. A qualitative synthesis of the evidence was performed according to the nine BHC and the SCC model. Scientific evidence indicates that COVID-19 vaccination meets four of the nine BHC as a protective factor against post-COVID cardiovascular conditions, namely strength of association, consistency, temporality, and biological gradient. Three criteria, biological plausibility, coherence, and analogy, were partially met. Specificity and experimental evidence were not supported by the available literature. The SCC model highlights the fundamental role of vaccination as a preventive causal component. It also contributes to two criteria, strength of association and temporality, while emphasising the limitation of specificity in causal inference. COVID-19 vaccination has proven effective beyond the acute phase of the disease, with protection extending to a reduced risk of post-COVID cardiovascular conditions. Comprehensive immunisation strategies and reinfection prevention are essential to mitigate the burden of post-COVID conditions. Additional studies are needed to explore the underlying biological mechanisms, interactions, and the role of COVID-19 vaccination in preventing post-COVID complications.

Indexed as

Cardiovascular DiseasesCOVID-19COVID-19 VaccinesHumansPost-Acute COVID-19 SyndromeSARS-CoV-2VaccinationCOVID-19 Vaccinescardiovascular diseasescausalityCOVID‐19COVID‐19 vaccinespost‐COVID conditions

Identifiers

PMID42858449
PMCPMC13653686

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.