Evidence map›Paper›PMID 42858446›Full record

ArticleDermatology practical & conceptual2026

Interplay of Biological Treatment and Psychological Features in Patients with Psoriasis: A Real-Life Prospective Study.

Gaia Moretta, Tonia Samela, Alessia Provini, Gianluca Pagnanelli, Dario Graceffa, Diego Orsini, Viviana Lora, Antonio Giovanni Richetta, Annunziata Dattola, Simone Amato and 14 more

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Article in Dermatology practical & conceptual, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Gaia MorettaClinical Dermatology Department, IDI-IRCCS, Rome, Italy.
Tonia SamelaClinical Epidemiology, Clinical Psychology Unit, IDI-IRCCS, Rome, Italy.
Alessia ProviniAsl Roma 2, Ospedale Sandro Pertini, Rome, Italy.
Gianluca PagnanelliClinical Dermatology Department, IDI-IRCCS, Rome, Italy.
Dario GraceffaSan Gallicano Dermatological Institute, IRCCS, Rome, Italy.
Diego OrsiniSan Gallicano Dermatological Institute, IRCCS, Rome, Italy.
Viviana LoraSan Gallicano Dermatological Institute, IRCCS, Rome, Italy.
Antonio Giovanni RichettaDermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, Rome, Italy.
Annunziata DattolaDermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, Rome, Italy.
Simone AmatoDermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, Rome, Italy.
Nicoletta BernardiniDermatology Unit, Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Fiorini Hospital, Polo Pontino, Terracina, Italy.
Paola TribuziDermatology Department, Ospedale di Belcolle, Viterbo, Italy.
Arianna ZangrilliDermatology Unit, System Medicine Department, University of Tor Vergata, Rome, Italy.
Martina VultaggioDermatology Unit, System Medicine Department, University of Tor Vergata, Rome, Italy.
Luca BianchiDermatology Unit, System Medicine Department, University of Tor Vergata, Rome, Italy.
Giacomo CaldarolaInstitute of Dermatology, Università Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Eleonora De LucaInstitute of Dermatology, Università Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Clara De SimoneInstitute of Dermatology, Università Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Domenico GiordanoDermatology Unit, Sant'Andrea Hospital University of Rome, Rome, Italy.
Cinzia MasiniDermatology Department, Ospedale San Sebastiano, Frascati, Roma, Italy.
Mauro BavettaDermatology Department, Ospedale San Sebastiano, Frascati, Roma, Italy.
Stefania LechiancoleClinical Dermatology Department, IDI-IRCCS, Capranica, Italy.
Vincenzo PanasitiDepartment of Plastic, Reconstructive and Cosmetic Surgery, Dermatology Unit, Campus Bio-Medico, Rome, Italy.
Damiano AbeniClinical Epidemiology, Clinical Psychology Unit, IDI-IRCCS, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEmotional dysregulation (ED), common among patients with psoriasis, leads to psychopathology and impairs treatment adherence.

objectiveThis study examined the changes in prevalence of ED in patients and its effects on illness perception, mental health, and quality of life (QoL) during one year of treatment with risankizumab.

methodED, illness perception, general health, and QoL were measured at baseline, and at four, 16, and 52 weeks posttreatment in 58 patients with psoriasis.

resultsHigher ED was associated with greater psychological distress and poorer QoL. Patients with higher levels of ED reported greater psychological distress, worse QoL, and higher symptom-related distress throughout treatment as compared to those with lower ones. Although both groups improved in terms of illness perception and clinical severity outcomes, patients with high ED consistently experienced worse subjective outcomes.

conclusionED is frequent in psoriasis patients and negatively affects mental health and QoL, despite clinical improvements in skin symptoms. Targeted psychological interventions may be necessary for patients who exhibit higher levels of emotional dysregulation to ensure comprehensive care and better long-term outcomes.

Identifiers

PMID42858446
PMCPMC13557251

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.