Evidence map›Paper›PMID 42858415›Full record

ReviewDermatology practical & conceptual2026

Shared Pathways between Psoriasis and Atopic Dermatitis.

Federica Trovato, Camilla Chello, Simone Amato, Antonio Di Guardo, Emanuele Amore, Luigi Bennardo, Antonio Giovanni Richetta, Teresa Grieco, Steven Paul Nisticò, Giovanni Pellacani and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dermatology practical & conceptual, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Federica TrovatoDermatology Unit, Istituto Dermopatico dell'Immacolata IDI-IRCCS, Rome, Italy.
Camilla ChelloDermatology Unit, Istituto Dermopatico dell'Immacolata IDI-IRCCS, Rome, Italy.
Simone AmatoDermatology Unit, Istituto Dermopatico dell'Immacolata IDI-IRCCS, Rome, Italy.
Antonio Di GuardoDermatology Unit, Istituto Dermopatico dell'Immacolata IDI-IRCCS, Rome, Italy.
Emanuele AmoreDermatology Unit, Istituto Dermopatico dell'Immacolata IDI-IRCCS, Rome, Italy.
Luigi Bennardo
Antonio Giovanni RichettaDermatology Unit, Department of Medical and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Teresa GriecoDermatology Unit, Department of Medical and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Steven Paul NisticòDermatology Unit, Department of Medical and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Giovanni PellacaniDermatology Unit, Department of Medical and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Annunziata DattolaDermatology Unit, Department of Medical and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPsoriasis and atopic dermatitis are leading examples of chronic inflammatory dermatoses with distinct clinical manifestations, pathogenesis, and demographic patterns. However, recent research has revealed overlapping immunological pathways that could serve as promising therapeutic targets.

objectivesTo synthesize the principal immunological, epidermal barrier, and microbiome pathways shared by psoriasis and atopic dermatitis and to discuss their potential translational and therapeutic implications.

methodsWe conducted a narrative review of the literature on PubMed from January 2000 to June 2024, using keywords such as "psoriasis," "atopic dermatitis," "cytokine pathways," "T cells," and "environmental triggers." Studies were selected based on their relevance to shared mechanisms between these diseases, focusing on cytokine profiles, immune cell activity, and skin barrier dysfunction.

resultsOur review identified significant overlaps in cytokine-mediated pathways, particularly the IL-17/IL-22 axis, which mediates keratinocyte hyperproliferation and inflammation in both diseases. T cell dysregulation, including Th17 and Th22 activity, plays a pivotal role in maintaining chronic inflammation. Both conditions also exhibit impaired skin barrier function, linked to filaggrin loss-of-function mutations in atopic dermatitis and abnormal keratinocyte differentiation in psoriasis.

conclusionThese findings suggest that targeting shared mechanisms, such as the Th17 and Th22 pathways, along with barrier repair strategies may enable dual therapeutic benefits. This review underscores the potential for integrative treatment approaches and personalized medicine in managing chronic inflammatory skin disorders.

Identifiers

PMID42858415
PMCPMC13557259

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.