ArticleJournal of veterinary internal medicine2026
Global longitudinal strain assessment of systolic dysfunction in Doberman Pinschers with ventricular arrhythmias and normal echocardiographic measurements.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDilated cardiomyopathy (DCM) in Doberman Pinschers (DPs) often initially manifests as ventricular arrhythmias (stage B1) without echocardiographic evidence of cardiac remodeling (stage B2). Global longitudinal strain (GLS) is a sensitive echocardiographic variable for detecting early systolic dysfunction. HYPOTHESIS/
objectivesTo assess whether GLS detects systolic dysfunction in DPs with arrhythmogenic stage B1 and to evaluate the association between arrhythmic burden and GLS. ANIMALS: Sixty-three DPs with arrhythmogenic stage B1 DCM and 63 control DPs.
methodsRetrospective case-control study. Stage B1 was defined as ≥300 ventricular premature complexes (VPCs) within 24 h or >50 VPCs on two 24-h Holter recordings within 1 year, with otherwise normal echocardiographic measurements. Forty-three dogs had "last-normal" (LN) examinations 6-12 months before arrhythmia onset. GLS was measured using 2-dimensional speckle-tracking echocardiography (STE) from left apical 2-, 3-, and 4-chamber views. Stage B1 dogs were subclassified into low-grade (LGvpc) and high-grade (HGvpc) groups based on arrhythmic burden.
resultsGLS was lower in stage B1 dogs (mean ± SD, -16.80% ± 2.71%) compared to controls (-20.22% ± 1.90%; P = .044). Stage B1 dogs had lower GLS compared to their LN examinations (mean difference, -2.45%; 95% CI, -3.67% to -1.24%; P < .001). Dogs in the HGvpc group had lower GLS (-15.45% ± 2.79%) than LGvpc dogs (-18.39% ± 1.51%; mean difference, -2.94%; 95% CI, -4.28% to -1.60%; P < .001).
conclusionsGLS detects systolic dysfunction in DPs with arrhythmogenic stage B1 DCM despite normal conventional echocardiographic measurements. Higher arrhythmic burden is associated with more severe systolic dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.