Evidence map›Paper›PMID 42858257›Full record

ArticleSTAR protocols2026

Protocol for an immunocompetent KPC mouse model of pancreatic cancer resection and recurrence for perioperative treatment studies.

Jacob L Léger, Nawal Amhis, Sarah Mansouri, Maria Fernanda Meza Pacheco, Lauren Daniel, Hugo Giguère, Yves Collin, Lee-Hwa Tai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jacob L LégerDepartment of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Nawal AmhisDepartment of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Department of Surgery, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Sarah MansouriDepartment of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Department of Surgery, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Maria Fernanda Meza PachecoDepartment of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Lauren DanielDepartment of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Hugo GiguèreDepartment of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Yves CollinCentre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Department of Surgery, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Lee-Hwa TaiDepartment of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada; Centre de Recherche Du Centre Hospitalier de L'Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada. Electronic address: lee-hwa.tai@usherbrooke.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In mouse models of pancreatic ductal adenocarcinoma, surgical removal of orthotopic tumors typically involves removing the primary tumor along with the spleen. Here, we present a protocol for surgical removal of the tumor in the tail of the pancreas while preserving the spleen. We describe steps for implantation of mouse pancreatic cancer cells followed by the identification and removal of the orthotopic tumor. We also outline perioperative treatment strategies for tumor recurrence.

Indexed as

CancerImmunologyModel Organisms

Identifiers

PMID42858257
PMCPMC13675828

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.