Evidence map›Paper›PMID 42858211›Full record

ArticleVeterinary research communications2026

Concurrent fibrinogen Aα-chain amyloidosis and AA amyloidosis in a Humboldt penguin (Spheniscus humboldti).

Susumu Iwaide, Natsumi Kobayashi, Mako Ikudome, Shiho Takezawa, Yoshiyuki Itoh, Tomoyuki Shibahara, Keisuke Kawase, Tomoaki Murakami

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PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Susumu IwaideResearch Unit of Innovative One Medicine, Advanced Research Center for One Welfare, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai- cho, Fuchu, Tokyo, Japan. fq3733@go.tuat.ac.jp.ORCID https://orcid.org/0009-0005-0601-9137
Natsumi KobayashiLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Fuchu, Tokyo, Japan.
Mako IkudomeLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Fuchu, Tokyo, Japan.
Shiho TakezawaIbaraki Prefectural Kenpoku Livestock Hygiene Service Center, 966-1 Nakagachi-cho, Mito, Ibaraki, Japan.
Yoshiyuki ItohSmart-Core-Facility Promotion Organization, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, Japan.
Tomoyuki ShibaharaNational Institute of Animal Health, National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, Ibaraki, Japan.
Keisuke KawaseHitachi Kamine Zoo, 5-2-22, Miyata-cho, Hitachi, Ibaraki, Japan.
Tomoaki MurakamiLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Fuchu, Tokyo, Japan.

Funding

Japan Society for the Promotion of Science 23H02380Japan Society for the Promotion of Science 26K18215
6 · The paper itself

Abstract

Amyloidosis is a disease characterized by the deposition of abnormally folded proteins as amyloid fibrils in tissues and occurs in various mammals and birds. In some cases, amyloids derived from two different precursor proteins may coexist in the same individual, a condition known as double amyloidosis. Amyloid A (AA) amyloidosis is known to occur frequently in birds; however, little is known about other types of amyloidosis. In the present study, we report a case of amyloidosis in a Humboldt penguin involving two distinct types of amyloids. Histopathological examination, transmission electron microscopy, mass spectrometry-based proteomic analysis, and immunohistochemistry revealed the concurrent occurrence of fibrinogen Aα-chain (FibA) amyloidosis and AA amyloidosis. FibA-derived and AA amyloid deposits exhibited distinct nodular and diffuse morphologies, respectively, suggesting that their deposition patterns may provide a morphological clue for distinguishing between the two types of amyloids. To our knowledge, this is the first case of FibA amyloidosis in a penguin and the first report of the concurrent occurrence of two distinct types of systemic amyloidosis in a bird.

Indexed as

AmyloidosisBird DiseasesFibrinogenSpheniscidaeAnimalsImmunohistochemistryMicroscopy, Electron, TransmissionSerum Amyloid A ProteinFibrinogenfibrinogen AalphaSerum Amyloid A ProteinAvianDouble amyloidosisDual amyloidosisPenguinSerum amyloid A

Identifiers

PMID42858211
PMCPMC13653883

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