ArticleRedox report : communications in free radical research2026
Sulfur amino acid restriction and caloric restriction induce divergent redox metabolism-related adaptations in male F344 rats.
Article in Redox report : communications in free radical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionTo discover novel mechanisms, we compared changes in redox metabolism markers induced by caloric restriction (CR) and sulfur amino acid restriction (SAAR).
methodsWe fed 16-week-old male F344 rats either a control diet (CD, 0.86% methionine), a sulfur amino acid-restricted diet (SAAR, 0.17% methionine), or a control diet pair-fed to 60% of the CD's
resultsCompared with CR, SAAR decreased the hepatic total free glutathione (tGSH), increased GSSG:tGSH, protein-bound GSH:tGSH, and lowered glucose-6-phosphate dehydrogenase levels, indicating a pro-oxidant milieu. SAAR and CR differentially affected the NADPH-generating enzymes. SAAR increased the cytosolic malic enzyme (ME1) without affecting mitochondrial ME3, while CR increased ME3, but not ME1. CR elevated cytosolic methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) without affecting mitochondrial MTHFD2, whereas SAAR increased MTHFD2 without affecting MTHFD1. Folate cycle changes include increases in
conclusionsSAAR and CR engage different pathways to generate compartment-specific NADPH. Protein glutathionylation may contribute to SAAR-induced benefits.
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