ArticleJournal of the American Heart Association2026
Polygenic Determinants of Arterial Stiffness: Implications for Hypertension.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundComponents of arterial stiffness (structural stiffness from aging and load-dependent stiffness from high blood pressure [BP]) are markers for cardiovascular disease risk. We evaluated relationships between polygenic risk scores (PRSs) for BP and arterial stiffness.
methodsParticipants (n=5804) are from MESA (Multi-Ethnic Study of Atherosclerosis) with measures of carotid ultrasound and genomic DNA. Carotid pulse wave velocity (PWV) was calculated from carotid ultrasound. Structural stiffness was calculated by adjusting carotid PWV to a 120/80 mm Hg BP with participant-specific models. Load-dependent stiffness was the difference of total and structural stiffness. BP PRSs were derived from genome-wide associations. Associations were assessed with multivariable-adjusted regression models. Mendelian randomization was performed with 2-stage least squares.
resultsParticipants were aged 62.8±10.3 years. Systolic BP (SBP) was 133.5±20.5 mm Hg, diastolic BP (DBP) was 74.27±10.28 mm Hg, and pulse pressure was 59.22±16.17 mm Hg. Total carotid PWV was associated with the SBP PRS (β=0.10±0.02,
conclusionsThere are key differences in the genetic underpinnings of the mechanistic components of arterial stiffness.
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