Evidence map›Paper›PMID 42857895›Full record

ArticleCNS neuroscience & therapeutics2026

Interaction Between Peripheral Cytokines and Central Neuroinflammation in Temporal Lobe Epilepsy.

Heyu Zhang, Ningning Wang, Yuying Zhang, Siqi Ou, Jingjing Chen, Jinming Zhang, Yicong Liu, Yuting Luo, Yingting Luo, Ziheng Wei and 4 more

Abstract read
In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Heyu ZhangDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.ORCID https://orcid.org/0000-0001-9700-6975
Ningning WangDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.ORCID https://orcid.org/0009-0002-4414-6282
Yuying ZhangDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0003-3761-4332
Siqi OuDepartment of Neurosurgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-9213-6997
Jingjing ChenDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.ORCID https://orcid.org/0009-0002-3931-2055
Jinming ZhangDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.
Yicong LiuDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.ORCID https://orcid.org/0009-0009-1745-9321
Yuting LuoDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.
Yingting LuoDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.
Ziheng WeiDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.
Kailin WuDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.
Xiangsong ZhangDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-1730-9923
Ziyi ChenDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.ORCID https://orcid.org/0000-0001-6790-1258
Guanzhong NiDepartment of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.ORCID https://orcid.org/0000-0002-2334-3423

Funding

Guangdong Province International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases 2020A0505020004Guangdong Provincial Clinical Research Center for Neurological Diseases 2020B1111170002Guangdong Provincial Engineering Center for Major Neurological Disease TreatmentGuangdong Provincial Translational Medicine Innovation Platform for Diagnosis and Treatment of Major Neurological DiseaseGuangzhou Clinical Research and Translational Center for Major Neurological DiseasesNational Key Research and Development Program of China 2022YFC2503804National Natural Science Foundation of China 81801287National Natural Science Foundation of China 81971203National Natural Science Foundation of China 82001234National Natural Science Foundation of China 82271489Science and Technology Program of Guangzhou, China 2024A04J4564
6 · The paper itself

Abstract

purposeNeuroinflammation is a key pathogenic mechanism in temporal lobe epilepsy, quantifiable in vivo using positron emission tomography targeting the translocator protein. This study integrated [

methodsA prospective study of 24 TLE patients and 24 healthy controls (HCs) was conducted. PET/MRI data were available for 24 TLE patients and 7 HCs, while cytokine data were available for all 24 participants in both groups. Standardized uptake value ratios of [

resultsCompared with HCs, TLE patients demonstrated significantly increased [

conclusion[

Indexed as

CytokinesEpilepsy, Temporal LobeNeuroinflammatory DiseasesAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyProspective StudiesPyrazolesPyrimidinesYoung AdultCytokinesN,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamidePyrazolesPyrimidinesneuroinflammationPET/MRIserum cytokinestemporal lobe epilepsytranslocator protein

Identifiers

PMID42857895
PMCPMC13653323

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.