ArticleSleep science (Sao Paulo, Brazil)2026
Exploring the Link Between Inflammatory Gene Variants and Phenotypes of Periodontal Disease and Obstructive Sleep Apnea.
Article in Sleep science (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Periodontal disease (PD) and obstructive sleep apnea (OSA) are prevalent chronic inflammatory conditions affecting over 50% of Colombians and a substantial proportion of the global population. This study investigated genetic associations between interleukin (IL) gene variants (IL-1β, IL-10, IL-17) and the risk of PD, OSA, or their coexistence in 129 Colombian individuals, including cases (PD, OSA, PD + OSA) and healthy controls. Genotyping was performed using PCR amplification and Sanger sequencing. Key findings revealed that IL-1β variants (rs1143627, rs16944) significantly increased OSA risk (OR = 3.6 and 3.36;
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