ArticleAsian journal of neurosurgery2026
SOX17: Insight into the Genesis of Intracranial Aneurysm.
Article in Asian journal of neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the association of the SOX17 gene with intracranial aneurysm (IA) and its expression in a patient with IA. Materials and Methods: Patients visiting the Department of Neurosurgery from March 2020 to December 2021 were screened for IA on the basis of clinical criteria of sudden-onset headache, loss of consciousness, etc. The diagnosis of subarachnoid hemorrhage was made on plain computed tomography (CT; head), and the presence of IA was confirmed by CT angiography brain and/or on cerebral digital subtraction angiography. Confirmed patients were enrolled in the study after taking informed written consent. A case-control design was used, with 50 IA patients as cases and 50 age- and sex-matched normal individuals from the community who were healthy subjects with no risk factors for IA formation as controls. Results: The 50 patients with IA included 48% females and 52% males, with age ranging from 26 to 78 years (mean age: 50.84 ± 12.33 years). The majority (26 patients) of patients were in the age groups of 40 to 60 years, 16 patients were above 60 years, and only 8 cases were below the age of 40 years. The 50 healthy control subjects included 16 females and 34 males, with age ranging from 30 to 67 years (mean age: 51.12 ± 10.29 years). Both cases and controls were found to be similar in terms of age distribution ( Conclusion: From our study, we conclude that there is a significant positive association between SOX17 gene with IA, hence this gene has been found to be overexpressed. As a result, this may be used as a simple, minimally invasive blood screening tool to assess the risk of IA formation in high-risk group individuals.
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