Evidence map›Paper›PMID 42857854›Full record

ArticleAsian journal of neurosurgery2026

Atypical Lhermitte-Duclos Disease Presenting as a Malignant Cerebellar Tumor: NeuN-Positive Neuronal Differentiation as a Diagnostic Clue.

Jignesh Joshi, Srikant Banumathy, Srikant Balasubramaniam, Sweety Shinde

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PubMed Full text at PMC Publisher
In one paragraph

Article in Asian journal of neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Jignesh JoshiDepartment of Neurosurgery Bai Yamunabai Laxman Nair Charitable Hospital and Topiwala National Medical College, Mumbai, Maharashtra, India.
Srikant BanumathyDepartment of Medicine, Indian Institute of Technology Bombay Hospital, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India.
Srikant BalasubramaniamDepartment of Neurosurgery Bai Yamunabai Laxman Nair Charitable Hospital and Topiwala National Medical College, Mumbai, Maharashtra, India.
Sweety ShindeDepartment of Pathology, Bai Yamunabai Laxman Nair Charitable Hospital and Topiwala National Medical College, Mumbai, Maharashtra, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lhermitte-Duclos disease (LDD), or dysplastic cerebellar gangliocytoma, is a rare benign cerebellar lesion that may present with atypical imaging and histopathological features, resulting in diagnostic uncertainty and potential overtreatment. We report a 32-year-old woman who presented with progressive headache, vomiting, vertigo, and right-sided cerebellar ataxia. Magnetic resonance imaging revealed a large right cerebellar lesion extending into the vermis, middle cerebellar peduncle, and hemipons, with inhomogeneous contrast enhancement and diffusion restriction, closely mimicking a malignant posterior fossa tumor. The patient underwent suboccipital craniotomy and decompression. Histopathology demonstrated distorted cerebellar folia with depletion of the Purkinje cell layer and expansion of the granular layer by neurocytic cells, raising a diagnostic dilemma with medulloblastoma. Immunohistochemistry showed NeuN and synaptophysin positivity with a very low K

Indexed as

dysplastic cerebellar gangliocytomaimmunohistochemistryLhermitte–Duclos diseaseNeuNposterior fossa lesions

Identifiers

PMID42857854
PMCPMC13652604

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