ArticleAsian journal of neurosurgery2026
Comparison of Outcomes between Supramaximal Resection and Gross Total Resection for High-Grade Gliomas: A Prospective Study from a Tertiary Care Centre.
Article in Asian journal of neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: High-grade gliomas (HGG), including glioblastomas and anaplastic gliomas, are among the most aggressive primary brain tumors with poor prognosis despite multimodal treatment. Surgical resection remains the cornerstone of management, with gross total resection (GTR) traditionally considered the standard operative goal. However, recent evidence supports supramaximal resection (SMR)-removal of the enhancing tumor along with a margin of infiltrating non-enhancing tumor-as a strategy that may improve progression-free survival and overall survival (OS) without significantly increasing neurological morbidity. Materials and Methods: Fifty-six adult patients with histologically confirmed Grade 3 or 4 gliomas undergoing surgical resection between January 2024 and May 2025 were enrolled. Patients underwent either SMR ( Results: The cohort had a mean age of 47.6 years, with a male predominance (69.6%). Histopathology distribution showed 46.4% glioblastomas, 25% astrocytomas, and 23.2% oligodendrogliomas. Preoperative and postoperative KPS scores were higher in the SMR group though differences were not statistically significant ( Conclusion: SMR appears to offer improved oncological outcomes in terms of recurrence and survival compared with GTR for HGG in this cohort, without increased perioperative morbidity. The findings support consideration of SMR as a safe and potentially more effective surgical strategy for appropriately selected patients, emphasizing the importance of functional preservation and modern intraoperative guidance.
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