Unraveling the molecular details of centriole elongation.

Anastasia Amoiroglou, John M Ryniawec, Brian J Galletta, Nasser M Rusan, Gregory C Rogers

Abstract read

In one paragraph

Article in Trends open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anastasia AmoiroglouDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA.

John M RyniawecDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA.

Brian J GallettaCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Nasser M RusanCell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Gregory C RogersDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA.

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026

$110.2M

Regulation of Centrosome Asymmetry in Stem CellsZIAHL006126 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI RUSAN, NASSER · 2011 to 2025

$19.4M

Characterizing the molecular mechanisms of centriole duplication, growth and maturationR35GM136265 · NIGMS · UNIVERSITY OF ARIZONA · PI Gregory Charles Rogers · 2020 to 2026

$3.9M

Intramural NIH HHS ZIA HL006126NCI NIH HHS P30 CA023074NIGMS NIH HHS R35 GM136265

6 · The paper itself

Abstract

Centrosomes are the major microtubule-organizing centers in most metazoan cells. At their core sit cylindrical centrioles composed of nine radially symmetrical microtubules blades and an evolutionarily conserved assemblage of unique proteins. Length of the centriole barrel varies across species, in different cell-types within the same animal, and between centrioles in the same cell. Furthermore, defects that alter centriole length can lead to chromosomal instability, tumorigenesis, infertility, and ciliopathies. In this review, we summarize our current understanding of how centrioles elongate, the molecular components involved, and their functional interplay.

Identifiers

PMID42857736

DOI10.1016/j.treopn.2026.04.003

PMCPMC13652109

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.