ReviewMycology2026
Morphological differentiation and its application in industrial filamentous fungi.
Review in Mycology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Filamentous fungi are essential ecosystem members and major platforms for industrial biomanufacturing, where their morphological differentiation strongly influences broth rheology, mass/oxygen transfer, secretion efficiency, stress tolerance, and ultimately productivity. However, the intricate network in which process-specific cues are sensed and integrated to reprogram the endogenous developmental pathways remains incompletely understood, limiting rational morphology engineering of the industrial filamentous fungi. This review summarizes recent advances in the regulation of morphological differentiation of filamentous fungi, integrating internal and external signaling along with molecular control of spore germination, polarity establishment, hyphal extension/branching, and cell wall-plasma membrane homeostasis. We discuss how distinct morphologies affect performance in submerged and solid-state fermentation, and we overview the practical control strategies including inoculation design, environmental and hydrodynamic optimization, microparticle-enhanced cultivation, and genetic reprogramming. Finally, we highlight emerging monitoring approaches and recent progress in machine learning and modeling within AI-enabled biomanufacturing, proposing an integrated gene-morphology-function-titer perspective for next-generation fungal cell factories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.