Evidence map›Paper›PMID 42857713›Full record

ArticleiScience2026

Inducible dCas12a system expands CRISPRi/a capabilities for functional genomics in malaria parasite

Amuza Byaruhanga Lucky, XiaoLian Li, George Kobakhidze, Jose Lulo Gonzales, Chengqi Wang, Liwang Cui, Gang Dong, Jun Miao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amuza Byaruhanga LuckyDepartment of Internal Medicine, University of South Florida, 3720 Spectrum Blvd, Tampa, FL, USA.
XiaoLian LiDepartment of Internal Medicine, University of South Florida, 3720 Spectrum Blvd, Tampa, FL, USA.
George KobakhidzeMax Perutz Labs, Vienna Bio-center, Center for Medical Biochemistry, Medical University of Vienna, Dr. Bohr-Gasse 9/3, 1030 Vienna, Austria.
Jose Lulo GonzalesCollege of Engineering, Department of Medical Engineering, University of South Florida, 4202 E. Fowler Avenue, ENG 030, Tampa, FL, USA.
Chengqi WangCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, 3720 Spectrum Blvd, Tampa, FL, USA.
Liwang CuiDepartment of Internal Medicine, University of South Florida, 3720 Spectrum Blvd, Tampa, FL, USA.
Gang DongMax Perutz Labs, Vienna Bio-center, Center for Medical Biochemistry, Medical University of Vienna, Dr. Bohr-Gasse 9/3, 1030 Vienna, Austria.
Jun MiaoDepartment of Internal Medicine, University of South Florida, 3720 Spectrum Blvd, Tampa, FL, USA.

Funding

Development of CRISPR/dCas-based epigenetic gene regulation tools in malaria parasiteR21AI149202 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI MIAO, JUN · 2020 to 2021
$411k
NIAID NIH HHS R21 AI149202
6 · The paper itself

Abstract

We developed inducible dead Cas12a (dCas12a)-based CRISPR interference/activation (CRISPRi/a) systems for

Indexed as

CRISPRdCas12agene regulationhuman malariaPlasmodium falciparum

Identifiers

PMID42857713
PMCPMC13651822

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.