Trial reportPeerJ2026
Neural substrates of knowledge integration: differential effects of high-definition transcranial direct current stimulation (HD-tDCS) on angular gyrus and ventrolateral prefrontal cortex.
Trial report in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Humans develop extensive knowledge systems throughout their lives, which are continuously updated in response to new information. One way in which prior knowledge is updated is through semantic integration, where related semantic facts are integrated to support derivation of new information. Methods: This study investigates how anodal high-definition transcranial direct current stimulation (HD-tDCS) applied to the left angular gyrus (AG; Experiment 1) or to the left ventrolateral prefrontal cortex (vlPFC; Experiment 2) influences semantic integration and the derivation of novel information. In both studies, participants were first randomly assigned to a stimulation or sham group. Following the stimulation protocol, they were presented with a series of intermixed pairs of related facts and asked to rate their familiarity with each. Participants then completed a semantic integration test following a brief delay, answering questions about novel information that could be derived by integrating the related facts. Participants' integration scores (primary outcome) and their correlations with general intelligence (IQ) (secondary outcome) were measured. Building on exploratory findings from Experiment 1, Experiment 2 was pre-registered to test the impact of stimulation on the correlation between IQ and integration. Results: There was no overall mean difference in integration scores between stimulation groups and their sham stimulation counterparts (all Conclusion: Self-derivation of new knowledge is a complex, multifactorial process that was not uniquely enhanced by stimulation of the left AG or vlPFC. However, these regions appear to differentially modulate performance by reducing variability for lower-performing individuals (AG) or decoupling the dependence of performance on baseline cognitive capacity (vlPFC).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.