Evidence map›Paper›PMID 42857679›Full record

ArticleRegenerative biomaterials2026

The role of agrin as a downstream mediator of Slit3 in osteogenic-angiogenic interaction under osteoporosis.

Xu Ye, Zhenghao Xu, Gan Zhong, Wenge He, Yichi Zhang, Leilei Qin, Cheng Chen, JianYe Yang, Li Chen, Huan Yao and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xu YeDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zhenghao XuDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Gan ZhongDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Wenge HeDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Yichi ZhangDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Leilei QinDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Cheng ChenDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
JianYe YangDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Li ChenDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Huan YaoDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Yingkun HuDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Chengqiang ZhouDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Qinyang ZhangDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Huimei LiangDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xuan GongDepartment of Outpatient Care, Chongqing General Hospital, Chongqing 401147, China.
Denghui XieDepartment of Joint Surgery and Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Orthopedic Hospital of Guangdong Province, Guangzhou 510630, China.
Baicheng HeDepartment of Pharmacology, Chongqing Medical University, Chongqing 400016, China.
Zhong Alan LiDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR 999077, China.ORCID https://orcid.org/0000-0002-6009-629X
Ning HuDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis, characterized by an imbalance between bone formation and bone resorption, is currently treated mainly by inhibiting resorption or promoting formation. However, these therapeutic strategies are often limited in efficacy because they fail to simultaneously target the coupled osteogenic and angiogenic processes in bone metabolism. In recent years, Slit3 has emerged as a key regulator of osteo-angiogenic interaction and is now considered a promising therapeutic target for metabolic bone disease. In the present study, we performed

Indexed as

Agrinorgan-on-a-chiposteo-angiogenic interactionosteoporosisSlit3

Identifiers

PMID42857679
PMCPMC13651701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.