ArticleInfection prevention in practice2026
Implementation of a multi-disciplinary antimicrobial stewardship program in a tertiary hospital in Boyacá, Colombia: a quasi-experimental evaluation of prescription quality and antibiotic use.
Article in Infection prevention in practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Antimicrobial stewardship interventions are essential for optimizing antibiotic use and combating resistance. We implemented a multi-disciplinary, non-restrictive Antimicrobial Stewardship Program (ASP) at a tertiary hospital in Boyacá, Colombia. Objective: The aim of this study was to evaluate the effect of the ASP on antimicrobial consumption prescription patterns. Methods: A quasi-experimental study was used to compare antimicrobial prescriptions before (June-December 2023) and after (January-July 2024) ASP implementation. Adult inpatients receiving broad-spectrum antimicrobials for ≥48 h were included in the study. Prescription appropriateness and dose/schedule deviations were evaluated through prospective audit and feedback by a multi-disciplinary team. Consumption was measured using defined daily doses per 100 patient-days. A probit regression model was used to assess the association between prescriber type and prescription appropriateness. Confounding was addressed using a directed acyclic graph to determine the minimal adjustment set. Results: Out of 3845 prescriptions from 2491 patients, a significant improvement was observed in dosing accuracy and appropriateness of prescriptions after ASP implementation ( Conclusion: The ASP improved antimicrobial prescribing and reduced use of selected broad-spectrum antibiotics. Sustained improvements may require further efforts targeting surgical services and institutional integration.
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