ArticleOphthalmology science2026
Associations between Retinal Nerve Fiber Layer Thickness, Axial Length, and Generation in the 2-Continent Eye Study.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Purpose: To assess the associations between peripapillary retinal nerve fiber layer thickness (RNFLT) and ocular and systemic parameters, in particular axial length (A). Design: Population based studies. Methods: Ocular and systemic examinations including OCT RNFLT measurement. Participants: Participants of 4 population-based studies (Beijing Eye Study [n = 3246; age: 40+ years], Ural Eye and Medical Study [n = 5023; age: 40+ years], Ural Very Old Study [n = 407; age: 85+ years], Ural Children Eye Study [UCES, n = 3109; age: 6+ years]). Outcome Measures: RNFLT. Results: The study cohort consisted of 23 384 eyes (11 785 individuals). In multivariable analysis with exclusion of eyes with an IOP of >21 mmHg, thicker RNFLT was associated (all Conclusions: The AL-related increase in RNFLT up to an AL of 24 mm, found in all ages, may correspond to an AL-related larger retinal surface area with a higher number of retinal ganglion cells per eye. The RNFLT decrease beyond an AL of 26.5 mm in adults corresponds to an increased prevalence of optic neuropathies in highly myopic eyes. The sectorial differences in the RNFLT/AL relationship corresponds to the axial elongation-related RNFL shift to the macula, with a secondary RNFL crowding temporally and a geometrically explained RNFLT decrease nasally. Sectorial normative RNFLT data depend on AL. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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