Evidence map›Paper›PMID 42857431›Full record

ArticleRSC medicinal chemistry2026

PCA-mapping and machine learning identify multiple chemotypes with antiplasmodial, β-haematin and haemozoin formation inhibition activity.

Nicole Teixeira, Leah Amod, Clinton G L Veale, Timothy J Egan, Kathryn J Wicht

Abstract read
In one paragraph

Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicole TeixeiraDepartment of Chemistry, Faculty of Science, University of Cape Town Rondebosch Cape Town South Africa kathryn.wicht@uct.ac.za.ORCID https://orcid.org/0000-0002-2698-0890
Leah AmodDepartment of Chemistry, Faculty of Science, University of Cape Town Rondebosch Cape Town South Africa kathryn.wicht@uct.ac.za.ORCID https://orcid.org/0000-0002-8213-9211
Clinton G L VealeDepartment of Chemistry, Faculty of Science, University of Cape Town Rondebosch Cape Town South Africa kathryn.wicht@uct.ac.za.ORCID https://orcid.org/0000-0002-4043-7106
Timothy J EganDepartment of Chemistry, Faculty of Science, University of Cape Town Rondebosch Cape Town South Africa kathryn.wicht@uct.ac.za.ORCID https://orcid.org/0000-0001-7720-8473
Kathryn J WichtDepartment of Chemistry, Faculty of Science, University of Cape Town Rondebosch Cape Town South Africa kathryn.wicht@uct.ac.za.ORCID https://orcid.org/0000-0001-6145-9956

Funding

New tools for antimalarial target identificationR01AI143521 · NIAID · UNIVERSITY OF CAPE TOWN · PI WICHT, KATHRYN JEAN · 2019 to 2023
$709k
NIAID NIH HHS R01 AI143521
6 · The paper itself

Abstract

Inhibiting the formation of haemozoin remains a robust, non-genomic target for antiplasmodial drug discovery. While current efforts focus on multistage active compounds that are not pure haemozoin formation inhibitors, this class offers advantages including selectivity for

Identifiers

PMID42857431
PMCPMC13650541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.