Unicentric hyaline-vascular Castleman disease of the jejunal mesentery mimicking a gastrointestinal stromal tumor or neuroendocrine tumor: a case report.

Background: Castleman disease (CD) is a rare lymphoproliferative disorder classified as unicentric (UCD) or multicentric (MCD). The hyaline vascular variant of UCD most commonly arises in the mediastinum, whereas mesenteric involvement is exceedingly rare. As it can mimic hypervascular mesenteric tumors like neuroendocrine tumors (NETs) and gastrointestinal stromal tumors (GISTs), preoperative diagnosis remains challenging. Case presentation: A 36-year-old woman presented with a 3-month history of vague abdominal discomfort, early satiety, and an unintentional 9-kg weight loss. Contrast-enhanced CT revealed a hypervascular jejunal mesenteric mass of size 2.0 × 1.7 cm, suspicious for a NET or GIST. Owing to the diagnostic uncertainty, exploratory laparoscopy converted to a mini-laparotomy with Conclusion: Mesenteric unicentric CD is a rare but important differential diagnosis of solitary hypervascular intra-abdominal masses. As imaging findings often mimic mesenchymal and NETs, definitive diagnosis relies on histopathological and immunohistochemical evaluation. Complete surgical resection is both diagnostic and curative for localized disease.