ReviewFrontiers in endocrinology2026
Omentin-1 and cardiovascular disease: a comprehensive review from molecular mechanisms to clinical translation.
Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Omentin-1 is an adipokine predominantly secreted by visceral adipose tissue (VAT) and is abundant in human plasma. Circulating omentin-1 levels are significantly reduced in patients with obesity, type 2 diabetes mellitus (T2DM), hypertension, and coronary artery disease (CAD). However, the associations between circulating omentin-1 levels and cardiovascular risk and prognosis appear heterogeneous across populations and disease stages. Accumulating evidence indicates that omentin-1 exerts multiple cardioprotective effects. These effects include anti-atherosclerotic activity, improved insulin sensitivity, anti-inflammatory and antioxidant effects, enhanced endothelial function, and myocardial protection. Through these mechanisms, omentin-1 contributes to vascular and cardiometabolic homeostasis. This review summarizes the biological characteristics of omentin-1 and its protective roles and molecular mechanisms in CVD. It also highlights recent advances in clinical research. We further highlight emerging evidence that commonly used cardiometabolic drugs can modulate omentin-1 levels, supporting its potential as both a biomarker and a therapeutic target. A clearer understanding of its pleiotropic actions may facilitate the development of translational strategies for CVD prevention and treatment.
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