Evidence map›Paper›PMID 42857391›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Depression severity and sleep efficiency's associations with amyloid burden are additive but dependent on underlying genetic risk in late life depression.

Anita Shankar, Maria Kryza-Lacombe, Philip S Insel, Edith Harris, Michelle T Kassel, Lizabeth Goldstein, Andrew D Krystal, Susan M Landau, Duygu Tosun, Meryl A Butters and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Anita ShankarDepartment of Psychiatry and Behavioral Sciences University of California, San Francisco San Francisco California USA.ORCID https://orcid.org/0000-0002-6808-6811
Maria Kryza-LacombeDepartment of Psychiatry and Behavioral Sciences University of California, San Francisco San Francisco California USA.
Philip S InselDepartment of Psychiatry and Behavioral Sciences University of California, San Francisco San Francisco California USA.
Edith HarrisDepartment of Psychiatry and Behavioral Sciences University of California, San Francisco San Francisco California USA.
Michelle T KasselDepartment of Psychiatry and Behavioral Sciences University of California, San Francisco San Francisco California USA.
Lizabeth GoldsteinDepartment of Psychiatry and Behavioral Sciences University of California, San Francisco San Francisco California USA.
Andrew D KrystalDepartment of Psychiatry and Behavioral Sciences University of California, San Francisco San Francisco California USA.
Susan M LandauNeuroscience Department Helen Wills Neuroscience Institute University of California Berkeley Berkeley California USA.
Duygu TosunDepartment of Radiology and Biomedical Imaging University of California, San Francisco San Francisco California USA.
Meryl A ButtersDepartment of Psychiatry School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA.
Paul AisenDepartment of Neurology Keck School of Medicine University of Southern California Los Angeles California USA.
Rema RamanDepartment of Neurology Keck School of Medicine University of Southern California Los Angeles California USA.
Arthur W TogaLaboratory of Neuro Imaging Stevens Neuroimaging and Informatics Institute Keck School of Medicine University of Southern California Los Angeles California USA.
Clifford R JackMayo Clinic Rochester Minnesota USA.
J Craig NelsonDepartment of Psychiatry and Behavioral Sciences University of California, San Francisco San Francisco California USA.
R Scott MackinDepartment of Psychiatry and Behavioral Sciences University of California, San Francisco San Francisco California USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Evidence linking late-life depression (LLD) to amyloid beta (Aβ) burden remains mixed, possibly in part due to limited examinations of the confounding role of comorbid sleep disturbance and the moderating role of the apolipoprotein E ( Methods: We analyzed 110 older adults (ages 65-88, 66% female) with LLD to jointly model depression severity and sleep disturbance's relationship with Aβ, and to examine the moderating role of Results: Depression severity, sleep efficiency, and sleep duration did not demonstrate a direct relationship with Aβ; however, a significant Discussion: Depression severity and sleep efficiency's relationship with Aβ may be dependent on the presence of the

Indexed as

agingAlzheimer's diseaseamyloid betaapolipoprotein E ɛ4late‐life depressionsleep

Identifiers

PMID42857391
PMCPMC13650511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.