ArticleFrontiers in veterinary science2026
Erythrocyte membrane lipidomic signatures in canine lymphoma: immunophenotype-specific alterations and prognostic associations.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Lipid metabolic dysregulation is increasingly recognized as a hallmark of cancer. Erythrocyte membrane fatty-acid (FA) profiling may reflect systemic metabolic alterations and provide non-invasive biomarkers of tumor biology. This prospective study investigated the erythrocyte membrane lipidomic profile of dogs with lymphoma and its potential prognostic relevance. Thirty-nine dogs with newly diagnosed lymphoma were enrolled. Clinical staging, flow-cytometric immunophenotyping, and erythrocyte membrane FA analysis were performed at diagnosis. Individual FAs, FA classes, and lipid-derived indices were compared between B-cell and T-cell lymphomas. Lymphoma-specific survival (LSS) was evaluated using Kaplan-Meier analysis and exploratory univariate Cox proportional hazards models. Twenty-five dogs had B-cell lymphoma, and 14 had T-cell lymphoma. T-cell lymphomas were more frequently extranodal, whereas B-cell lymphomas were predominantly multicentric. Palmitoleic acid was significantly lower in T-cell than in B-cell lymphoma. Correlation analysis revealed distinct lipidomic interaction patterns in dogs with lymphoma compared with healthy controls, particularly involving polyunsaturated fatty acids, omega-6 fatty acids, arachidonic acid, and the unsaturation index.
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