SynthesisFrontiers in microbiology2026
Global research trends and emerging frontiers of gut microbiota-drug interactions: a bibliometric and visualization analysis (2003-2025).
Synthesis in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The gut microbiota can alter drug metabolism, efficacy, and toxicity, while medications can reciprocally reshape microbial communities. However, the structure and maturation of research specifically addressing these bidirectional interactions have not been comprehensively mapped. Methods: The Web of Science Core Collection (WoSCC) was the sole source for bibliometric mapping because it provides standardized cited-reference metadata. PubMed was used only for complementary search-strategy validation. We analyzed 9,242 English-language articles and reviews published from 2003 through 2025 using VOSviewer, CiteSpace, and bibliometrix. A seeded random sample of 100 WoSCC records was assessed at title/abstract level to evaluate search specificity. Results: The 9,242-publication corpus showed sustained growth, reaching 2,160 publications in 2025. For descriptive comparison, the study period was divided Conclusion: This large-scale bibliometric analysis maps the development of gut microbiota-drug interaction research while distinguishing established clusters from topics identified as recent frontiers. The findings support growing translational interest but should not be interpreted as evidence of clinical efficacy or research quality.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.