ArticleFrontiers in cardiovascular medicine2026
Baseline BMI and weight change in dilated cardiomyopathy: associations with LVEF, BNP, and NYHA class.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Baseline body mass index (BMI) and longitudinal weight change capture different clinical dimensions. We examined their concurrent associations with 12-month changes in left ventricular ejection fraction (LVEF), B-type natriuretic peptide (BNP), and New York Heart Association (NYHA) functional class among patients with dilated cardiomyopathy. Methods: Of 600 records screened, 322 patients had complete paired baseline and 12-month measurements and were included in this retrospective cohort analysis. Percentage weight loss was calculated as 100 × (baseline weight-12-month weight)/baseline weight; negative values denoted weight gain. Joint models included baseline BMI and weight loss and adjusted for age, sex, log-transformed baseline BNP, baseline LVEF, left ventricular end-diastolic diameter, baseline NYHA class, diabetes, chronic kidney disease, atrial fibrillation, and coronary atherosclerosis. Results: Thirty-six patients gained weight, six demonstrated no weight change, and 280 lost weight. Baseline BMI was not independently associated with LVEF change ( Conclusions: Twelve-month weight change was associated with concurrent changes in LVEF, BNP, and functional status, whereas baseline BMI was not. These data do not establish temporal direction, causality, or the superiority of weight change as a clinical marker.
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