ArticleFrontiers in microbiology2026
Tight junction suppression by candidalysin promotes gut-to-blood dissemination of
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The commensal fungus Methodology/principal findings: A murine model and human colonic epithelial cells (NCM-460) were used to investigate the effect of candidalysin on fungal dissemination and its association with changes in tight-junction protein abundance and distribution. Conclusion/significance: The dose-dependent effects of candidalysin on epithelial junction-associated proteins support a context-dependent contribution to intestinal pathogenesis. These findings associate candidalysin with epithelial injury and dissemination in the present model but do not establish a binary molecular switch or a candidalysin-exclusive mechanism. Elucidating how candidalysin coordinates epithelial and immune pathways provides new insight into the mechanisms that sustain gut-fungal symbiosis and may reveal therapeutic targets to preserve mucosal integrity and prevent systemic candidiasis.
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