Evidence map›Paper›PMID 42856999›Full record

ArticleFrontiers in pediatrics2026

A case-control study of necrotising enterocolitis in very low birth weight neonates at a tertiary hospital in South Africa.

Nkatha Meme, Ajayi Oluseyi Mojisola, Tanusha Ramdin

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Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nkatha MemeDepartment of Paediatrics and Child Health, University of the Witwatersrand and Charlotte Maxeke Johannesburg Academic Hospital, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Ajayi Oluseyi MojisolaDepartment of Paediatrics and Child Health, University of the Witwatersrand and Charlotte Maxeke Johannesburg Academic Hospital, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Tanusha RamdinDepartment of Paediatrics and Child Health, University of the Witwatersrand and Charlotte Maxeke Johannesburg Academic Hospital, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Between January 2018 to June 2020, 119 of 1,106 Very Low Birth Weight (VLBW) neonates admitted to Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) were diagnosed with Necrotising Enterocolitis (NEC), representing 10.8% of the VLBW neonates. This retrospective matched case-control study (119 cases, 119 controls; matched 1:1 on birthweight ±100 g, gestational age ±2 weeks, and postnatal age ±1 week) aimed to determine the prevalence, risk factors, and outcomes of NEC in VLBW neonates at a tertiary hospital in South Africa. We handled missing data using Multiple Imputation by Chained Equations (MICE, M = 20) after confirming the data were Missing at Random. We used MI-pooled conditional logistic regression for all analyses to account for the matched design. The mortality rate among NEC cases was 49.6%. On univariate analysis, outborn status (cOR 3.69, 95% CI 1.84-7.43), conventional ventilation (cOR 4.73, 95% CI 2.52-8.88), late-onset sepsis (cOR 6.29, 95% CI 3.02-13.07), and fungal sepsis (cOR 6.50, 95% CI 2.27-18.62) were significantly associated with NEC. In the multivariable analysis, conventional ventilation (acOR 3.37, 95% CI 1.42-8.01,

Indexed as

case controlconditional logistic regressionmultiple imputationnecrotizing entercolitissepsisSouth Africavery low birth weight (VLBW)

Identifiers

PMID42856999
PMCPMC13649688

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