Evidence map›Paper›PMID 42856958›Full record

ArticleCytoJournal2026

Folate receptor-positive circulating tumor cells as a potential biomarker for breast cancer diagnosis.

Juan Li, Jing Fu, Dandan Zhang, Gang Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CytoJournal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Juan LiDepartment of Breast Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Jing FuDepartment of Breast Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Dandan ZhangDepartment of Breast Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Gang HuDepartment of Breast Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.ORCID https://orcid.org/0009-0002-3352-8429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study investigated the potential of folate receptor-positive circulating tumor cells (FR+CTCs) as a non-invasive biomarker for breast cancer diagnosis and clinical stratification. Materials and Methods: Between January 2024 and October 2024, 179 breast cancer patients and 38 patients with benign breast diseases were enrolled at Sichuan Provincial People's Hospital, China. FR+CTCs were isolated from peripheral blood using the CytoploRare® kit and quantified via real-time polymerase chain reaction. Diagnostic accuracy was assessed using receiver operating characteristic (ROC) analysis. Results: FR+CTC levels were significantly higher in breast cancer patients compared to those with benign diseases ( Conclusion: FR+CTCs demonstrate significant potential as a non-invasive biomarker for breast cancer, showing high diagnostic accuracy and associations with key clinical characteristics. While promising, these findings warrant validation in larger, more diverse populations.

Indexed as

Breast cancerCirculating tumor cellsDiagnosisHuman epidermal growth factor receptor 2 statusTumor node metastasis stage

Identifiers

PMID42856958
PMCPMC13650584

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.