ArticleFrontiers in cellular and infection microbiology2026
Development of a novel organoid-based two-dimensional system to model the intestinal host-parasite interface in fasciolosis.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The earliest interactions between Methods: ODMs representing the human duodenum were co-cultured with either live FhNEJ or a tegument-enriched protein fraction derived from the parasites. The ODM co-culture system was subsequently employed to assess FhNEJ viability and parasite-epithelial interactions together with complementary functional and molecular read-outs. These included measurements of trans-epithelial electrical resistance, fluorescein permeability assays, immunofluorescence analysis of intercellular epithelial junctions, and quantitative proteomic profiling. Results: The ODM-FhNEJ co-culture system supported sustained parasite viability and enabled direct visualisation of intimate parasite-epithelial interactions. Functional and structural analyses revealed epithelial barrier dysfunction upon exposure to FhNEJ, whilst quantitative proteomics generated an exploratory molecular dataset identifying candidate proteins associated with epithelial junction organisation, immune signalling, cellular stress, and mechanotransduction. Conclusion: Together, these findings establish human intestinal ODMs as a physiologically relevant experimental platform for investigating the earliest stages of
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