ArticleFrontiers in neurology2026
Association of deep vein thrombosis with poststroke epilepsy after acute ischemic stroke: a multicenter retrospective cohort study.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Deep vein thrombosis (DVT) and poststroke epilepsy (PSE) are clinically important complications after acute ischemic stroke. DVT commonly occurs in patients with greater neurological impairment, immobility, inflammation, and hypercoagulability, factors that may also be associated with PSE. Whether DVT is independently associated with PSE remains uncertain. Methods: We conducted a secondary analysis of a multicenter cohort of 21,459 patients with acute ischemic stroke followed for 1 year. The association between recorded DVT and PSE was examined using sequential logistic regression models adjusting for demographic characteristics, vascular comorbidities, stroke severity, and lesion phenotype. Multicollinearity, sensitivity analyses, subgroup analyses, and joint stratification by DVT and National Institutes of Health Stroke Scale (NIHSS) score were performed. The incremental predictive value of DVT was evaluated using the area under the receiver operating characteristic curve (AUC), Brier score, calibration, and decision curve analysis. Results: Among 21,459 patients, 1,324 (6.2%) had DVT and 936 (4.4%) developed PSE. DVT was associated with higher odds of PSE in the unadjusted analysis (OR, 1.93; 95% CI, 1.56-2.39), and the association remained similar after adjustment for demographic and vascular factors. After further adjustment for NIHSS score, cortical lobe involvement, and anterior and posterior circulation involvement, the association was substantially attenuated and no longer statistically significant (OR, 1.10; 95% CI, 0.86-1.39; Conclusions: The association between DVT and 1-year PSE was largely explained by stroke severity and lesion phenotype. DVT provided little incremental predictive information beyond established clinical characteristics, supporting its interpretation as a marker of a more severe and clinically complex poststroke phenotype rather than an independent PSE risk factor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.