ArticleOpen forum infectious diseases2026
Tuberculosis Risk in the Returning Traveler: Assessing Tuberculosis Test Conversion Among Routinely Tested Patients at an Asian American Health Center.
Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: In the United States, testing for latent tuberculosis (TB) infection is recommended for persons from higher-TB-prevalence countries, but guidelines do not address repeat testing for persons with international travel. Methods: Using 2010-2022 data from a Californian federally qualified health center serving an Asian American population, we measured the incidence of TB test conversion (negative to positive result) and proportion of test converters receiving treatment among routinely tested patients (ie, patients with no history of TB infection, at least one prior negative result, and annual or biennial TB testing). We performed a nested case-control study to measure the association between TB test conversion and travel outside the United States. Results: Of 5668 patients receiving routine TB testing at annual/biennial frequencies, conversions occurred in 117 patients with TB skin tests (2.9%) and 52 patients with interferon-gamma release assays (3.2%); the overall test conversion incidence rate was 2.1/100 person-years. Latent TB infection treatment was initiated in 57% of test converters. Two patients were diagnosed with TB disease after test conversion, representing a 2-year TB incidence rate of 0.35/100 person-years. Patients with documented international travel had a 1.95-fold increased odds of TB test conversion (95% confidence interval 1.07-3.57) compared to patients without documented travel, with most travel occurring in medium or high-TB-prevalence countries. Conclusions: Within a 13-year study period, among a routinely tested population at higher risk of TB infection due to race and nativity, risk of TB test conversion was low. However, recent travel to higher-TB-prevalence settings nearly doubled the odds of TB test conversion.
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