ArticleFrontiers in cellular and infection microbiology2026
Genomic convergence of mobilome-associated multidrug resistance and host-adaptation determinants in a postoperative
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To characterize the convergence of resistance determinants, plasmid-mediated dissemination, and host adaptation in the postoperative Methods: Long-read sequencing was used to generate a complete genome. Subsequent analyses assessed phylogeny, average nucleotide identity, resistance genes, and plasmid comparisons. Phenotypic validation included conjugation assays, bile salt tolerance, biofilm formation, and a Results: The RO0725 genome comprised one chromosome and five circular plasmids. RO0725 carried 14 antimicrobial-resistance genes distributed across the chromosome and three resistance-associated plasmids. Chromosomal determinants included intrinsic resistance-associated genes such as Conclusion: RO0725 represents a convergence of transferable multidrug-resistance plasmids and host-adaptation determinants. These findings indicate that
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